منابع مشابه
High CD33 expression levels in acute myeloid leukemia cells carrying the nucleophosmin (NPM1) mutation.
The CD33 antigen is expressed on the blast cells of most cases of acute myeloid leukemia and represents a suitable tumor-associated target antigen for antibody-based therapies. The aim of this study was to investigate the relationship between the CD33 levels quantified by mean fluorescence intensity and antibody binding capacity, and the presence/absence of NPM1 and FLT3 gene mutations in 99 ne...
متن کاملRapid detection of nucleophosmin (NPM1) mutations in acute myeloid leukemia by denaturing HPLC.
Application of the erythrocyte glutathione reductase assay in evaluating riboflavin nutritional status in a high school student population. Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supple-mentation. Recovery from impaired dark adaptation in nightblind pregnant Nepali women who receive small dail...
متن کاملHIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation
The nucleolus is a plurifunctional organelle with dynamic protein exchange involved in diverse aspects of cell biology. Additionally, the nucleolus has been shown to have a role in the replication of numerous viruses, which includes HIV-1. Several groups have reported HIV-1 vRNA localization within the nucleolus. Moreover, it has been demonstrated the HIV-1 Rev protein localizes to the nucleolu...
متن کاملAcute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
After the discovery of NPM1-mutated acute myeloid leukemia (AML) in 2005 and its subsequent inclusion as a provisional entity in the 2008 World Health Organization classification of myeloid neoplasms, several controversial issues remained to be clarified. It was unclear whether the NPM1 mutation was a primary genetic lesion and whether additional chromosomal aberrations and multilineage dysplas...
متن کاملPrognostic Impact of Nucleophosmin 1 (NPM1) Gene Mutations in Egyptian Acute Myeloid Leukemia Patients
OBJECTIVE Somatic mutations of the nucleophosmin gene (NPM1), which alter the subcellular localization of the product, are the most frequent mutations in patients with acute myeloid leukemia. The aim of the study was to assess the prevalence and prognostic impact of NPM1 gene mutations in adult AML patients. MATERIALS AND METHODS Polymerase chain reaction and single-strand conformation polymo...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2010
ISSN: 1768-3262
DOI: 10.4267/2042/32058